This study suggests that adolescents identifying as a gender minority are at higher risk for psychopathology compared with those identifying as both sexual minorities and cisgender. The results do not support the idea that multiple minority identification is universally associated with higher mental health risk. Instead, the results indicate that this risk varies across intersections of race/ethnicity and sexual and gender minority status. The results should be interpreted with caution in light of study limitations, including broad categorizations of sexual and gender identities.